上葉優位型肺線維症(PPFE)に関する業績のまとめ

更新日:10月23日

福岡大学呼吸器内科の渡辺憲太朗前教授による2012年の報告(”PPFE”におけるFVCの急速な低下)を先駆けとして、途中から石井と木下が加わり、私どもはこの10年間 PPFEに関する論文を世に出してきました。ここ数年は全てここ筑紫病院からの発信です。渡辺先生がびまん性肺疾患に関する調査研究班のPPFE部会長だった事もあり、全国規模の研究会や診断基準案の作成に関わることが出来ました。その後石井が副部会長を拝命し、今年度が最終年度となりましたが、部会長が所属する東京医科歯科大学とも協同して、さらに踏み込んだ研究が進むことが期待されます。



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  10. Proliferation of elastic fibres in idiopathic pulmonary fibrosis: a whole-slide image analysis and comparison with pleuroparenchymal fibroelastosis. Kinoshita Y, Watanabe K, Ishii H, Kushima H, Fujita M, Nabeshima K. Histopathology. 2017 Dec;71(6):934-942.

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  13. Significant increases in the density and number of lymphatic vessels in pleuroparenchymal fibroelastosis. Kinoshita Y, Watanabe K, Ishii H, Kushima H, Fujita M, Nabeshima K. Histopathology. 2018 Sep;73(3):417-427.

  14. Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan. Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group. Respir Med. 2018 Aug;141:190-197.

  15. Pleuroparenchymal fibroelastosis as a histological background of autoimmune diseases. Kinoshita Y, Watanabe K, Ishii H, Kushima H, Hamasaki M, Fujita M, Nabeshima K. Virchows Arch. 2019 Jan;474(1):97-104.

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  17. The upward shift of hilar structures and tracheal deviation in pleuroparenchymal fibroelastosis. Ishii H, Kinoshita Y, Kushima H, Ogura T, Watanabe K. Multidiscip Respir Med. 2019 Mar 7;14:10.

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  19. Lower-lobe predominant pleuroparenchymal fibroelastosis. Kinoshita Y, Watanabe K, Ishii H, Kushima H, Nabeshima K. Pathol Int. 2019 Sep;69(9):536-540.

  20. The similarities and differences between pleuroparenchymal fibroelastosis and idiopathic pulmonary fibrosis. Ishii H, Kinoshita Y, Kushima H, Nagata N, Watanabe K. Chron Respir Dis. 2019 Jan-Dec;16:1479973119867945.

  21. Remodeling of the pulmonary artery in idiopathic pleuroparenchymal fibroelastosis. Kinoshita Y, Ishii H, Kushima H, Johkoh T, Yabuuchi H, Fujita M, Nabeshima K, Watanabe K. Sci Rep. 2020 Jan 15;10(1):306.

  22. Role of alveolar collapse in idiopathic pleuroparenchymal fibroelastosis. Kinoshita Y, Ishii H, Kushima H, Fujita M, Nabeshima K, Watanabe K. Sarcoidosis Vasc Diffuse Lung Dis. 2020;37(2):212-217.

  23. Serum latent transforming growth factor-β binding protein 4 as a novel biomarker for idiopathic pleuroparenchymal fibroelastosis. Kinoshita Y, Ikeda T, Kushima H, Fujita M, Nakamura T, Nabeshima K, Ishii H. Respir Med. 2020 Sep;171:106077.

  24. The pathogenesis and pathology of idiopathic pleuroparenchymal fibroelastosis. Kinoshita Y, Ishii H, Nabeshima K, Watanabe K. Histol Histopathol. 2021 Mar;36(3):291-303.

  25. Physiological Criteria Are Useful for the Diagnosis of Idiopathic Pleuroparenchymal Fibroelastosis. Ikeda T, Kinoshita Y, Ueda Y, Sasaki T, Kushima H, Ishii H. J Clin Med. 2020 Nov 22;9(11):3761.

  26. Alveolar Epithelial Denudation Is a Major Factor in the Pathogenesis of Pleuroparenchymal Fibroelastosis. Zaizen Y, Tachibana Y, Kashima Y, Bychkov A, Tabata K, Otani K, Kinoshita Y, Yamano Y, Kataoka K, Ichikado K, Okamoto M, Kishaba T, Mito R, Nishimura K, Yamasue M, Nabeshima K, Watanabe K, Kondoh Y, Fukuoka J. J Clin Med. 2021 Feb 24;10(5):895.

  27. A proposed prognostic prediction score for pleuroparenchymal fibroelastosis. Kinoshita Y, Ikeda T, Miyamura T, Ueda Y, Yoshida Y, Kushima H, Fujita M, Ogura T, Watanabe K, Ishii H. Respir Res. 2021 Jul 30;22(1):215.

  28. Severe and progressive platythorax disproportionate to lung fibrosis: A rare variant of idiopathic pleuroparenchymal fibroelastosis. Ikeda T, Kinoshita Y, Ueda Y, Sasaki T, Kushima H, Ishii H. Respir Med Case Rep. 2021 Mar 19;33:101395.

  29. Platythorax progresses with lung involvement in pleuroparenchymal fibroelastosis. Ikeda T, Kinoshita Y, Miyamura T, Ueda Y, Yoshida Y, Kushima H, Ishii H. Respir Investig. 2022 Mar;60(2):293-299.

  30. Limited efficacy of nintedanib for idiopathic pleuroparenchymal fibroelastosis. Kinoshita Y, Miyamura T, Ikeda T, Ueda Y, Yoshida Y, Kushima H, Ishii H. Respir Investig. 2022 Jul;60(4):562-569.

  31. Lung involvement during the prediagnostic phase of idiopathic pleuroparenchymal fibroelastosis. Miyamura T, Kinoshita Y, Kushima H, Mukae H, Ishii H. ERJ Open Res. 2022 May 9;8(2):00548-2021.

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  33. Familial pleuroparenchymal fibroelastosis: an entity to be recognized. Kinoshita Y, Utsunomiya T, Koide Y, Wada K, Ueda Y, Yoshida Y, Kushima H, Ishii H. Respir Med and Res. 2022 82: 100954.

  34. Change in body weight reflects disease progression in pleuroparenchymal fibroelastosis. Kinoshita Y, Ishii H, et al. (under revision)

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